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This Concept Map, created with IHMC CmapTools, has information related to: thymus dependent vs independent B cell activation, TD requires MHC-II, Cytokines, CD40-CD40L signal, TD features Class Switching, NO class switching produce IgM ONLY (polyspecific (germline) Ab), Thymus dependent (TD) vs independent (TI) Naive B cells Carb. Ag (polysaccharide) -mostly microbial origin -lipopoly from gram(-) bacteria -polymerized flagellin -pneumococcal poly. type III -levans and dextrans, Thymus dependent (TD) vs independent (TI) Naive B cells Carb. Ag (polysaccharide) TI, Thymus dependent (TD) vs independent (TI) Naive B cells Protein Ag TD, TD requires Helper T-cell, B Cell Activation produce IgM, Thymus dependent (TD) vs independent (TI) Naive B cells Protein Ag -more common -mult. epitopes per Ag, protein b/d to peptides MHC-II binds to TH cells B Cell Activation, TI features usually directed towards marginal zones in spleen, Thymus dependent (TD) vs independent (TI) Naive B cells Carb. Ag (polysaccharide) often linear carbs w/ repeating epitopes that cross-link mult. BCRs, MHC-II, Cytokines, CD40-CD40L signal process (summary) 1st signal = Binding of Ag 2nd = via Ag presentation to T cell (1st make IgM then IgG after class switching), No strong clustering of Igs endocytosis protein b/d to peptides, TI features NO class switching, Helper T-cell process (summary) 1st signal = Binding of Ag 2nd = via Ag presentation to T cell (1st make IgM then IgG after class switching), strong clustering of Igs strong signal B Cell Activation, TI Ag binds at mult. sites strong clustering of Igs, TD Ag binds No strong clustering of Igs, TD requires Helper T-cell