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This Concept Map, created with IHMC CmapTools, has information related to: Endothelium & Vascular, Omega-3 Fatty Acids MOA increased peroxisomal beta-oxidation in liver, Oxidative stress caused by Increased LDL C, Pleiotropic Properties Such as Improved Endothelial Function, General dysfunction or narrowing of Arteries Symptoms of Cramping Pain Tired Legs/Hip Worsen with walking/Activity Subsides with rest, Omega-3 Fatty Acids Counseling Points Should be taken with a meal, Omega-3 Fatty Acids Recommended Therapy Patient Case: JE, Platelet Aggregation Resulting In Hemostasis, Smokes 1PPD Down from 2PPD over the last 30 years, Oxidative stress caused by smoking, diabetes caused by Increased Tissue ACE-A 2, Oxidative stress caused by Increased BP, Improved Endothelial Function Through Increased NO Bioactivity, Omega-3 Fatty Acids Adverse Effects heartburn, Warfarin Anticoagulant Blocks the regeneration of Vitamin K, Virchow's Triad ???? Hypercoagulability (Blood), Omega-3 Fatty Acids Effects On Cardiovascular, Pathophysiology ???? Decrease in NO Increase in local mediators Increase tissue ACE-A II, Patient Case: JE Characteristics HTN Diabetes High Cholesterol, Current Medications Include Warfarin, Decrease in NO Increase in local mediators Increase tissue ACE-A II VCAM/ICAM cytokines Inflammation