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This Concept Map, created with IHMC CmapTools, has information related to: 4-PAD-DVT, Venous Insufficency (PVD) manifestation skin changes, Factor IIa leads to with combination of fibrinogen Fibrin, 54 YOM, 250lb, truck driver current medications Warfarin 5mg, Factor IXa with factor VIIIa Factor Xa, Factor Xa with Factor II Factor IIa, Arterial insufficiency (PAD) Manifestation of Advanced PAD discoloration of toes, Factor Xa Inhibitor: Rivaroxaban obesity extremes of body weight do not significantly influence rivaroxaban avoid use in patients with BMI ᡠkg/m^2 or kg due to lack of clinical data, Endothelial dysfunction results from Imbalance of Endothelium-derived factors, Venous Insufficency (PVD) Progression Inadequate return of venous blood from legs to heart, formation of thrombus in arteries causes narrowed arteries commonly in pelvis and legs, PAD diagnoistic test ABI, 54 YOM, 250lb, truck driver current medications fish oil (Omega-3 fatty acid)?, Factor X with factor VIIIa Factor Xa, 54 YOM, 250lb, truck driver current medications Atorvastatin 20mg, Imbalance of Endothelium-derived factors vasoconstrictor effects angiotensin II, ASA (variable dose based on cost) inhibits only COX-1 at low dose, COX-1 & COX-2 at high doses preventing prostacyclin, Arterial insufficiency (PAD) Manifestation of Advanced PAD thin shiny skin, loss of hair and nail growth, HMG-CoA reductase cholesterol effects increased HDL, Imbalance of Endothelium-derived factors prothrombotic molecules von Willebrand factor