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This Concept Map, created with IHMC CmapTools, has information related to: Final, pyridostigmine (mestinon) con's doesnt treat immune problem, Bombardment of nAChR with ACh which causes Twitching, Down regulation of receptor associated conditions Anticholinesterase Poisoning, Myasthenia Gravis treatment Edrephonium, ACh inhibitors which Increase ACh, Myasthenia Gravis symptoms fatigue, Decrease nicotine receptor availability occurs via Bombardment of nAChR with ACh, Competetive Inhibition For example Edrophonium, 68.2-102.2 milligrams of Succinylcholine Onset of Action 60-90 seconds, Neutralize the toxin of nicotinic effects by Cleaving the OP-acetyl cholinesterase complexes that are still not aged, Acetylcholinesterase Inhibition leads to Increased levels of Acetylcholine, Organophosphates and Carbamate Poisioning Can be tested by Atropine Test, 30% of working dose for 1-2 Weeks, Delayed (24h to 2 weeks) Nicotinic Receptor Action Intermediate syndrome, Block ACh release from nerve ending Botulinum Toxin By inhibiting contraction, Atropine dosed intravenously 2-5 mg every 5 minutes doubling the initial dose, Acetylcholine acts on Ligand-gated Nicotinic Receptors, Train of Four (TOF) 2 mechanisms Irreversibly, 0.1 mg/kg IV if required for the reversal of muscle relaxation may repeat every 5 mins, Block ACh binding to esterase 2 mechanisms Irreversibly