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This Concept Map, created with IHMC CmapTools, has information related to: Week 11, Opening of fewer Voltage-Gated Na+ channels Resulting Skeletal muscle weakness, Edrophonium 150mg/15mL Dose: 0.1mg/kg (Short-Acting AChES inhibitor) one time dose 5 mg (0.5 mL/dose), Physiology Abnormal Reaction ACh, Myesthenia Gravis (MG) 20 yrs. Female 110 lbs. ???? Physiology, Nicontinic Receptor on Skeletal Muscle (Ligand Gated receptor) Opens Voltage-Gated Na+ channels, Voltage-Gated Na+ channels Resulting Skeletal Muscle Contraction, Drug Therapy Test Dose IV Neostigmine 5mg/10mL Dose: 0.1mg/kg (Short-Acting AChES inhibitor), Skeletal Muscle Contraction ending reaction Acetylcholinesterase breaks down ACh, Myesthenia Gravis (MG) 20 yrs. Female 110 lbs. ???? Drug Therapy, Physiology Normal Reaction ACh, ACh Binds to Nicontinic Receptor on Skeletal Muscle (Ligand Gated receptor), Clinical Presentation ???? - Droopy eyelid ~3 months - Muscle weakness in limbs especially after exertion, -Tiring of jaw when chewing -Difficulty swallowing food, ACh Blocked by Anitbodies Nicontinic Receptor on Skeletal Muscle (Ligand Gated receptor), Neostigmine 5mg/10mL Dose: 0.1mg/kg (Short-Acting AChES inhibitor) repeated after 5 minutes if required 5 mg (10mL/dose), Drug Therapy Maintainance Dose Oral Neostigmine 15mg tab Dose: 0.5mg/kg (AChES inhibitor), Drug Therapy Test Dose IV Edrophonium 150mg/15mL Dose: 0.1mg/kg (Short-Acting AChES inhibitor), Acetylcholinesterase breaks down ACh results in muscle relaxation, Nicontinic Receptor on Skeletal Muscle (Ligand Gated receptor) Results in Opening of fewer Voltage-Gated Na+ channels, Neostigmine 15mg tab Dose: 0.5mg/kg (AChES inhibitor) 25 mg every 8 hours Total Dosage: 75mg per day, Myesthenia Gravis (MG) 20 yrs. Female 110 lbs. ???? Clinical Presentation