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This Concept Map, created with IHMC CmapTools, has information related to: Myesthenia Gravis, Cholinergic Syndrome ???? AChE Inhibitors, Drug Therapy Test Dose IV Neostigmine 5mg/10mL Dose: 0.1mg/kg (Short-Acting AChES inhibitor), pulse increases by 25 bpm or skin flushing occurs indicates No OP toxicity, ACh Increases ACh in synapse, Clinical Presentation ???? - Droopy eyelid ~3 months - Muscle weakness in limbs especially after exertion, -Tiring of jaw when chewing -Difficulty swallowing food, Voltage-Gated Na+ channels Results in Skeletal Muscle Contraction, Efflux of ACh (pre-synaptic neuron) Agents: Black Widow Venom & Black Mamba Venom results in Increase of ACh in synapse, Physiology ???? Inhibition of AChE (post synaptic neuron) Agent: Cobra Venom & Organophosphates, Results in Relaxed Skeletal muscle Drug Therapy Botox, ACh Blocked by Anitbodies Nicontinic Receptor on Skeletal Muscle (Ligand Gated receptor), Drug Therapy Test Dose IV Edrophonium 150mg/15mL Dose: 0.1mg/kg (Short-Acting AChES inhibitor), Nicontinic Receptor on Skeletal Muscle (Ligand Gated receptor) Opens Voltage-Gated Na+ channels, Modifications to Acetylcholine Action ???? Non- depolarization (Pre-synaptic Neuron) Agent: Botulinum Toxin, Botox ???? Nondepolarizing Neuromuscluar Agent, ACh in neuron Closed Blocked results in Results in Relaxed Skeletal muscle, Reversible ???? Acridine, Results in Relaxed Skeletal muscle Drug Therapy Succinylcholine 20 mg/mL Dose: 1-1.5 mg/kg, Nicontinic Receptor on Skeletal Muscle (Ligand Gated receptor) Results in Opening of fewer Voltage-Gated Na+ channels, Myasthenia Gravis (MG) 20 yrs. Female 110 lbs. ???? Clinical Presentation, AChE Inhibitors ???? Reversible