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This Concept Map, created with IHMC CmapTools, has information related to: TEST, Acute & Chronic Asthma Physiology Hypoxia Hypercarbia Mucus secretion Inflammation Bronchoconstriction, Reduces inflammation drug used Hydrocortisone, Respiratory acidosis - Low pH - High PaCO2 Stage IV Hypoxemia with high PCO2 (Respiratory failure), Acute & Chronic Asthma Drug Prep and Dosing Tertbutaline, G Protein- Coupled receptors & bronchodilators Gq Anticholinergic M1 + M3, Acute & Chronic Asthma Drug Prep and Dosing Albuterol Sulfate, Albuterol Sulfate dosing Inhale 1.64 mL every 6 hours, Anticholinergic M1 + M3 parasympathetic blockage Blocks the release of ACh. Producing Bronchodilation, reducing the mucus volume drugs used Ipratropium bromide Tiotropium bromide, Bronchial smooth muscle dilation results opens airway and remove mucus, Acute & Chronic Asthma Pharmacology Receptors G Protein- Coupled receptors & bronchodilators, Glucocorticoid receptors GR translocation Reduces inflammation, Glucocorticoid receptors GRE binding Reduces inflammation, Ipratopium Bromide Dosing Administer 2.5 mL every 6 hours, Tertbutaline Dosing Administer 3270 mL per hour, Acute & Chronic Asthma Drug Prep and Dosing Hydrocortisone, B2 agonists sympathetic activation Bronchial smooth muscle dilation, Acute & Chronic Asthma Pharmacology Receptors Glucocorticoid receptors, Acute & Chronic Asthma Clinical Presentation Hyperventilation Wheezing Chest tightness Dyspnea Can't say 3 words without being breathless Use of accessory muscles Positioned sitting upright, Respiratory acidosis - Low pH - High PaCO2 Stage I Hyperventilation (Low PCO2 normal PO2)