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This Concept Map, created with IHMC CmapTools, has information related to: Boron Chapter 43 - Pancreatic and Salivary Glands, Activates phosphlipase C* Rate of enzyme secretion increases, Acinar cells Release 5 to 10X as many enzymes when stimulated by a nuerohumoral agent - regulated pathway*, Salivary Glands Include Submandibular gland, The Exocrine Pancreas Made up of Acinar cells, Secretes enzymes and zymogens (inactive enzymes) to aid in digestion* produced by Acinar cells, Regulated mostly by the autonomic nervous system Norepinephrine released by sympathetic nerve terminals, The Exocrine Pancreas Secretes enzymes and zymogens (inactive enzymes) to aid in digestion*, The most important regulators of pancreatic secretion are cholecystokinin (CCK) and acetylcholine (ACh) Both receptors are found on the basolateral surface of the acinar cells that faces the interstitial space, Acetylcholine released by postganglionic parasympathetic nerve terminals Responsible for maintaing normal saliva production and gland mass*, Pancreatic Enzymes Trypsinogen, Trypsinogen Converted by enterokinase (or enteropeptidase, same thing) in the small intestine to trypsin which is the active form, Synthesized and released by B cells in the Islets of Langerhans Triggers release of more amylase to digest carbohydrates (glucose), Cholecystokinin (CCK) Released by I cells in the dueodenum following ingestion of a meal, Stimulates the pancreas to increase its rate of protein secretion The most important regulators of pancreatic secretion are cholecystokinin (CCK) and acetylcholine (ACh), Humoral Insulin, Activates phosphlipase C* increases the rate of oscillation but not the amplitude of [Ca2+]i changes [Ca2+] oscillate slowly without any stimulation. This results in the slow constituitive release of pancreatic enzymes, Duct cells Main purpose is to transport electrolytes and secrete NaHCO3-rich fluid that accounts for 75% of pancreatic fluid, Regulated by neurohumoral stimuli Humoral, Activates phosphlipase C* increases the rate of oscillation but not the amplitude of [Ca2+]i changes Rate of enzyme secretion increases, Goblet cells Produce mucins, which get hydrated to form mucus