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This Concept Map, created with IHMC CmapTools, has information related to: Asprin, Pregnant uterine smooth muscle (contraction) Leads to Relaxation, Prostaglandins Involved with Inflammation vasodilation & increased capillary permeability, Liver Excreted Kidneys, Maintaining renal blood flow Leads to Decreased glomerular filtration rate, Pain (central & peripheral mediator release) Leads to Analgesia, Fever pyrogen production Lowers Body temperature, Aspirin Indications Reduction of MI risk, Prostaglandins Involved with Fever pyrogen production, Increased acid/pepsin levels, decreased mucous levels Acidic drug Mucosal irritation, Platelet cyclo-oxygenase (COX) a key enzyme in thromboxane A2 generation Inhibits Platelet aggregation, Aspirin Indications Prevention of thrombosis, Prostaglandins Involved with Stomach (lowers acid/pepsin secretion, increases mucous secretion), Converted to salicylic acid Metabolised Liver, Decreased glomerular filtration rate Which may induce Fluid and sodium retention, Inflammation vasodilation & increased capillary permeability Decreased Inflammation, Reduction of MI risk Oral dose Converted to salicylic acid, Platelet aggregation Increased Bleeding, Aspirin Indications Mild pain or fever, Aspirin Indications Anti-inflammatory eg. arthritis, Prostaglandins Involved with Maintaining renal blood flow