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This Concept Map, created with IHMC CmapTools, has information related to: GTN, Decreased SVR Decreases Cardiac afterload, Blood pressure Which may result in Reflex tachycardia, Glyceryl trinitrate (GTN) Metabolised Hydrolysis, Hydrolysis Eradicated by Kidneys (predominantly as mononitrate), Cardiac afterload Lessens Cardiac workload, Endothelial cells of the blood vessel wall Sulfhydryl-dependent catalyst converts GTN to Nitric oxide, Decreased venous return Decreases Venous return, Availability of calcium ions within the muscle cell As a result Blood vessels dilate, Blood vessels dilate Which may induce Facial flushing, Decreased SVR Decreases Blood pressure, Glyceryl trinitrate (GTN) Indications Hypertension associated with surgery, Prophylaxis/treatment for angina Sublingual/topical/transdermal administration It is taken up by Endothelial cells of the blood vessel wall, Activity of contractile protein myosin As a result Blood vessels dilate, Blood pressure Which may result in Hypotension, Cardiac preload Lessens Cardiac workload, Glyceryl trinitrate (GTN) Indications Prophylaxis/treatment for angina, Cyclic guanosine monophosphate (cGMP) Alters Activity of contractile protein myosin, Blood vessels dilate Which may induce Decreased SVR, Cyclic guanosine monophosphate (cGMP) Alters Availability of calcium ions within the muscle cell, Nitric oxide Increases intracellular levels of Cyclic guanosine monophosphate (cGMP)