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This Concept Map, created with IHMC CmapTools, has information related to: MELAS in class map, Phylloquinone (Vitamin K1) donates electrons to Cytochrome C, diagnostic studies including PCR, Lactate dehydrogenase activity increases during anaerobic glycolysis, MELAS characterized by lactic acidosis, Metabolic Therapies include DCA, diagnostic studies including Lumbar Puncture, Oxidative Phosphorylation deficiencies cause Low ATP production, CoQ10 reduces elevated lactic acid, cardiomyopathy are symptoms of MELAS, proteins which can affect Oxidative Phosphorylation, reactive oxygen species interact with electrons at CoQ, MELAS characterized by mitochondrial encephalmyopathy, Lumbar Puncture shows elevated lactate, pryuvate in CSF, increased NADH:NAD+ ratio causes switch to anaerobic glycolysis, Succinate Decreases frequency of stroke-like symptoms, Complex IV activity deficiency causes increased release of reactive oxygen species, aminoacylation affect mitochondrial protein synthesis, Low ATP production significantly affects CNS, Lactate dehydrogenase activity regulates increased NADH:NAD+ ratio, DCA increases pyruvate dehydrogenase (PDH) activity