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This Concept Map, created with IHMC CmapTools, has information related to: 08.30.11 CBL - Osteoporosis.cmap, "terrible back pain" described as non-radiating, Ca++ from the bone compensates for 25 OH-D3, decreased estrogen levels increase sensitivity to PTH, "terrible back pain" quantified as 7/10 at rest, bone formation is a hallmark of OSTEOPOROSIS, "terrible back pain" secondary to "gentle fall" on back, COX-2 inhibits synthesis of prostaglandins, "terrible back pain" localized to mid-back below scapula, loss of bone mass leads to fractures, PTH causing increased osteoclast activity, loss of bone mass is greater than bone formation, "terrible back pain" not relieved by Ibuprofen (800 mg Q6 hours), postmenopausal leads to decreased estrogen levels, Betty VanCleef presents with "terrible back pain", Betty VanCleef has high alkaline phosphatase, NSAID inhibits COX-2, intestinal epithelial cells increases txn of Ca++ receptor, "terrible back pain" quantified as 10/10 w/ movement, IL-6 increases apoptosis of osteoblasts, loss of bone mass which includes trabecular bone