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This Concept Map, created with IHMC CmapTools, has information related to: Case 3-4 Bacterial Infection, Virulence factors Catalase, Increaces Vascular permeability and endothelial adhesiveness Localized Edema Change in filtration coeficent, Pathogenicity Koch's Postulates Same agent must be recovered again from infected host, Classifications Gram + cocci, Catalase + Coagulase +, Size: 1-5um vs. eukaryotic 3-10 Cell Wall: Present in both Membrane: contains no sterol unlike eukaryots No nuclear membrane unlike eukaryots no nucleolus unlike eukaryots Both DNA and RNA Circular DNA vs linear chromosomes in eukaryots 70S ribosomes vs 80S ribosomes NO mitochondria unliek eukaryots mycoplasma is an exception, Tranmission Veneral Spread, Tranmission Vertebrate Reservoir, hyaluronidase Promotes Mobility, Increaces Vascular permeability and endothelial adhesiveness Increaces expression od P(released) and E(synthesized) selectins on endotheilal wall, Monocyte Macrophages Circulating Monocytes _> macrophages in tissue more lethal, Macrophages/Neutrophils/NKCells Neutrophils, C3 Cleaved To C3b, C5b,6,7 Joins to form C5b,6,7,8,9 Membrane Attack Complex, Peroxide Singlet Oxygen, Effect Recruit other cells, Resident macrophages Release IL1,6,TNFalpha causing amplification of acute phase protein synthesis Stimulates Leukocytosis, Exotoxins Kills off leukocytes, PSGL-1 binds to exposed slectins constians Slex activity Tethering and Rolling, Virulence factors hyaluronidase