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This Concept Map, created with IHMC CmapTools, has information related to: Case 3-2 Thallassemia, Erythroblasts :50: EpoR is lost, tRNA 15% nucleoplasm Synthesized by Pol 3, Allosteric effectors that modulate hemoglobin acffinity H+: the decreased pH in the periphery caused by acidic metabolites binds to the c terminus of the beat chain and stabalizes the deoxyHb state thus decreased pH reduces oxygen affinity, DNA Adenine methylase activity parent strand identified by methylation state (prokaryots only), Active Replication Complex (sphase) FEN1/RNase H1 removes RNA primers, Prokaryotic oriC is starting locus, Types of Damage Depurination: A/G Lost, MutL is recruited and forms a hairpin mlh in eukaryots, Remaining heme show smaller iron deviation (ɞ angstrom) Sucessive oxygens are easier to bind, Exonuclease creates 3' tail RAD51 (BRCA2)conjugates with free end and searches for homologue in another dsDNA, Types of Mutations Large insertion/deletions, Types of Damage oxidized bases ( 8 oxoguanine), intiates synthesis DNAg (Primase) RNA primers DNA polymerase uses RNA primer to intiiate polymerization, Bound for blood transport by Transferrin Fe3+ only TF receptors binds Transferrin: receptor mediated endocytosis, General Transcription Factors (GTF) UBF 1 and SL1 Synthesized by RNA Pol I and Pol 3(5s unit), HIF1 alpha and beta conugate to activate epo Epo, GATA1 indcues expression of Bcl-xL, Activity is mediated by "specific transcription factors" activators/repressors BIND BEFORE GTF Preinitation Complex Formed PIC, Post translational modifications Poly adenylated tail after AAUAAA code, Allosteric effectors that modulate hemoglobin acffinity Increased affinity, left shift Decreased affinity, right shift, Premature chain termination ??? No beta chain formed Beta zero defect usually causes: MAJOR