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DM Mel, Insulin Injections Insulin Humlin and Humlin NPH, Hyperglycemia macrovascular disease: coronary,peripheral, and cerebral artery disease., eventually when more then 90% of the pancreases beta cells are destroyed you see hyperglycemia, enhanced lypolysis, and protein catabolism. signs / symptoms headaches, fatigues lethargy, reduced energy levels due to low intracellular glucose levels., Increased byfactors that increase blood viscosity or reduce vessel diameter hyperplasia of the smooth muscle, Treatment Insulin Injections, hyperplasia of the smooth muscle thickened vessels with narrowed lumina leading to plaque formation, eventually when more then 90% of the pancreases beta cells are destroyed you see hyperglycemia, enhanced lypolysis, and protein catabolism. signs / symptoms polyuria and polydispia due to high serum osmoality from high glucose levels, eventually when more then 90% of the pancreases beta cells are destroyed you see hyperglycemia, enhanced lypolysis, and protein catabolism. signs / symptoms abnormally slow healing of skin infections or wounds, Neuropathy is a prgressive deterioration of the nerves that results in loss of nerve function Damage to autonomic nerve fibers results in loss of function, Damage to autonomic nerve fibers results in loss of function leads to clients Gastroparesis: A delay in gastric emtying