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MDD protein, BDNF has a major interaction with 5-HTTLPR allele, Cognition namely learning, CREB protein binds to cAMP, 5-HTTLPR allele see NB - KAUFMAN ET AL. 2006, BDNF enourages growth/ specification of synapses, BDNF found in Kidney Prostate Retina Motor Neurons, BDNF found in Brain, BDNF gene regulates CREB protein, Basal Forebrain involved in Cognition, social support (environment) see NB - KAUFMAN ET AL. 2006