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AZ genetics - DKS, Presenilin 1 gene (PSEN1); protein (PS1) known mutations over 90 known, high allele copy correlated with high probability of AD (Corder, 1993), Chromosome 1 overlaps with early onset AD, Presenilin 2 gene (PSEN2); protein (PS2) location Chromosome 1, Apolipoprotein E gene (APOE) in APOE type 4 high allele copy, include 3 plus one in promotor region found in type 1 Familial Alzheimer Disease (FAD), Amyloid Precursor Protein (APP) gene known mutations include 3 plus one in promotor region, Amyloid Precursor Protein (APP) gene leads to (Tomita, 1997) alteration causing, Presenilin 1 gene (PSEN1); protein (PS1) protein functions cleaves amyloid beta peptide from APP, Presenilin 1 gene (PSEN1); protein (PS1) protein functions as integral membrane protein