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This Concept Map, created with IHMC CmapTools, has information related to: Map 7, Congestion Itching Rhinorrhea Sneezing Caused by Histamine Leukotriene, Asthma & Rhinitis ???? Physiology, Inhibits phosphodiesterase Leads to Smooth muscle relaxation, PEFR Normal 80-100%, Arterial Blood Gases Metabolic Acidosis, FEV1/VC Normal ≥70%, Nonpharmacologic Treatment of Rhinitis ???? Fans & Filters, 39 yo Male 5'9" 175 lb Rhinitis Symptoms Cough, Antibody therapy (Omalizumab) MOA Binds to circulating IgE, decreasing cell bound IgE, Moderate Impairment Sleep Work/School Daily Life, Antibody therapy (Omalizumab) MOA Decreases expression of high affinity receptors, Nonpharmacologic Treatment of Rhinitis ???? Take off shoes, Asthma & Rhinitis Treatment Options Mast cell degranulation blockers (Cromolyn), Physiology Effect on Arterial Blood Gases, Intermittent Less than 4 days and 4 weeks, FEV1 Moderate 50-65%, Early Reactions Onset within minutes Congestion Itching Rhinorrhea Sneezing, 39 yo Male 5'9" 175 lb PMH PEFR = 250 L/min (pre), 310 L/min (post) pre-Albuterol: FVC 72%, FEV1 38% post-Albuterol (10min): FVC 73%, FEV1 49%, Process Sensitization Exposure to Antigen/ Proliferation of IgE, Alkalosis Decreased PaCO2