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This Concept Map, created with IHMC CmapTools, has information related to: Case 3-1 Ethylene Glycol Poisoning, Low blood pH sensed by central chemoreceptors in 4th ventricle Sensory Information Sent to Dorsal Respiratory Group in Medulla, Homocystine methionine, Consumption of Ethylene Glycol Low dose: intoxication/CNS depression without smell of Ethanol (lower volatility), NADH . Lactate, Formaldehyde Aldehyde Dehydrogenase (mitochondrial), Alcohol Dehydrogenase (primary) Glycoaldehyde, Note ventral medullary (exercise/forced inspiration) and pontine groups (inhibit inspiration (resting) participate as well Sensory Information Sent to Dorsal Respiratory Group in Medulla, Formic Acid increased Organic acids in Circulation, Low dose: intoxication/CNS depression without smell of Ethanol (lower volatility) High Dose: encephalopathy/ cerebral edema/ Seizures, Formate Severe metabolic acidosis, Acts on GABA-a receptors CNS Depression -> Coma, Ethanol Microsomal Ethanol Oxidizing System (if primary is overloaded), Consumption of Ethylene Glycol Ethylene Glycol, Ethanol Occupies active site of ADH, with higher binding affinity, Inappropriate Grief response Suicidal ideation, Competative inhibitor of ADH 8000x binding affinity of Ethanol for ADH, Excess NADH leads to misc. metabolic disorders Fatty Acid Metabolism impaired, High Dose: encephalopathy/ cerebral edema/ Seizures Increaces inhibitory activtiy and supresses excitatory activity in the brain, NADPH + O2 Microsomal Ethanol Oxidizing System (if primary is overloaded), Ethylene Glycol Alcohol Dehydrogenase (primary)