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This Concept Map, created with IHMC CmapTools, has information related to: nerve stimulation of the muscle, nerve stim. of skeletal muscle each skeletal muscle is individually stimulated by a motor neuron, depolarization of the motor end plate triggers an action potential that spreads along the sarcolemma and T-tubules action potental causes release of Ca into the cytosol, triggering muscle contraction, the action potential arriving at the axon terminal brings about the release of acetylcholine (ACH), which leads to the depolarization of the motor end details ACH binds to receptors, opening Na/K channels. Na enters muscle, causing muscle to become depolarized, each skeletal muscle is individually stimulated by a motor neuron the neuromuscular junction is a place where the axon terminal meets a muscle cell membrane, separated by a synaptic cleft, the neuromuscular junction is a place where the axon terminal meets a muscle cell membrane, separated by a synaptic cleft the action potential arriving at the axon terminal brings about the release of acetylcholine (ACH), which leads to the depolarization of the motor end, the action potential arriving at the axon terminal brings about the release of acetylcholine (ACH), which leads to the depolarization of the motor end depolarization of the motor end plate triggers an action potential that spreads along the sarcolemma and T-tubules, Shortening of muscle fiber by action potential is called excitation-contraction coupling. 1. Action potential propagates along the sarcolemma and down the T-tubules. 2. Action potential causes terminal cisternae of SR to release calcium ions into the sarcoplasm. 3. Calcium ions then bind to troponin, changing its shape, and exposing the actin active site.